Respiratory Function and Dysfunction in Parkinson-Type Neurodegeneration
نویسندگان
چکیده
منابع مشابه
Mitochondrial respiratory chain dysfunction: implications in neurodegeneration.
For decades mitochondria have been considered static round-shaped organelles in charge of energy production. In contrast, they are highly dynamic cellular components that undergo continuous cycles of fusion and fission influenced, for instance, by oxidative stress, cellular energy requirements, or the cell cycle state. New important functions beyond energy production have been attributed to mit...
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The last 2 decades represent a period of unparalleled advancement in the understanding of the pathogenesis of Parkinson disease (PD). The discovery of several forms of familial parkinsonism with mendelian inheritance has elucidated insights into the mechanisms underlying the degeneration of dopaminergic neurons of the substantia nigra that histologically characterize PD. α-Synuclein, the princi...
متن کاملMitochondrial Dysfunction in Neurodegeneration
The mitochondrial respiratory chain (RC) is responsible for providing most of the cellular energy in the form of ATP, and is also one of the main sites of reactive oxygen species (ROS) formation. The RC, consisting of five enzyme complexes in the inner mitochondrial membrane, is unique in its bipartite dependence on both nuclear and mitochondrial DNA (mtDNA). One example of this is mitochondria...
متن کاملLoss of P-type ATPase ATP13A2/PARK9 function induces general lysosomal deficiency and leads to Parkinson disease neurodegeneration.
Parkinson disease (PD) is a progressive neurodegenerative disorder pathologically characterized by the loss of dopaminergic neurons from the substantia nigra pars compacta and the presence, in affected brain regions, of protein inclusions named Lewy bodies (LBs). The ATP13A2 gene (locus PARK9) encodes the protein ATP13A2, a lysosomal type 5 P-type ATPase that is linked to autosomal recessive fa...
متن کاملTopic: Mitochondrial Dysfunction in Neurodegeneration
Neurodegenerative diseases such as Parkinson's disease (PD) are of growing public health concern in developed countries and the need for novel effective treatments continues to increase. Neurodegenerative diseases take many forms, reflecting the degeneration of different populations of neurons at different times from distinct causes, but many of them also share common features. Amongst the comm...
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ژورنال
عنوان ژورنال: Physiological Research
سال: 2020
ISSN: 1802-9973,0862-8408
DOI: 10.33549/physiolres.934405